Sadly SD does not have a the type of nightlife as LA or SF. You got a few places that bring in some decent people like Belo, Montage, Decos, On Broadway & Onyx Room. And a few fun small places to go to like the Kava Lounge, Air Condition, Airport Lounge. If you can I would take the 2hr ride up north and go out in LA tho, lol. almost 12 years ago
Head down to the Gaslamp and throw a dart. Clubs all around.
It doesn't come close to the LA or SF nightlife, but that's mostly because we San Diegans would rather hang out with friends at a brew pub (#1 craft beer city in the US) then pay cover charges and fight crowds for a $15 martini. about 10 years ago