We are going there on Sunday - all the research I have done would indicate that there are no specific vaccinations you should have, but it's always a good idea to make sure that your tetanus is up to date.
about 5 years ago
We have just completed the garden route. 4 weeks ago. No special medication needed for SA. It was fantastic, I assume you will be hiring a car, as this will be the best way to see it. You will love it.