Again, depending on your own personal interest and budget, where is the best place to stay is subjective. If you love shopping, then well-known Orchard Road will be best as it is smack right in the center of the shopping belt surrounded by fine and opulent hotels and shops.
If you love sea sport, then the island of Sentosa is great for it's varied sea and land activities.
If you addicted to gambling, our Integrated Resort World offer world class hotels with opulent casinos situated in it's premises with theme parks and world class rides and a Singapore Flyer similar to London Eye nearby.
If you like dining, history and culture, go to Little India or China Town for it's old world ambiance, shopping and good variety of ethnic food. about 8 years ago
One more thing added to Patrick's already-specific answer,two must-goes right here are Dempesy Hill and Holland Village.Dozens of exotic restaurants calling you.You can enjoy various sorts of food from all over the world.The two sites are pretty near.Have good fun! almost 8 years ago