Going to Rome in early October so should we pre-purchase a skip-the-line tour of the Vatican Sistine chapel etc and colosseum?
I would highly recommend a Vatican tour Http://www.myvaticantour.com/ (and normally I hate tours!!)
You can skip the line and get great info about what you are seeing. The o e we took was very much worth the money.
The Sistine Chapel, at the end of the "path" through the museums, is always crowded.
Plus here are my general Rome tips: http://traveleater.wordpress.com/rome-italy/ almost 8 years ago