I stayed in the same hotel - was comfortable.
Its central to some great little restaurants and cafes, but I ddint really feel too safe at night while walking by myself. I teamed up with some people and this was fine.
Its about a 5 minute tuk tuk ride to the central markets which is good.
A week would be more than enough for me in one place (ie Phnom Penh) - but it just depends on what your interests are. I like to take a day or two to get over any climate issues and culture shock before getting "into it". But thats me. almost 6 years ago