The Refugio Amazonas is a tourist hotel on the Tambopata River in Peru
We suggest to take the medicine, specially yellow fever
In the other side, if you consider going to the Brazilian Amazon, there is not required.
Besides, I have just returned from Manaus on Sunday and stayed in the MV Desafio Cruise and it was fantastic.
Don't forget that the Amazon River starts after the Solimoes and Black river merges.
If you have any doubt dont hesitate to contact me almost 6 years ago